Phytotherapy for treatment of cytokine storm in COVID­19

In 2020, a novel strain of coronavirus (COVID-19) has led to significant morbidity and mortality worldwide. As the date this writing, total 116 M cases been diagnosed worldwide leading 2.5 deaths. The number mortalities is directly correlated with rise innate immune cells (especially macrophages) in lungs that secrete inflammatory cytokines (IL-1? IL-6) development “Cytokine Storm Syndrome” (CSS), multi-organ-failure death. Given currently treatment condition rare release effective vaccine might be months away, here, we review plants their pharmacologically active-compounds as potential phytopharmaceuticals for virus induced response. Experimental validation effectiveness these natural compounds prevent or reduce cytokine storm beneficial an adjunct SARS-CoV-2.